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Allergy management reduces chronic periorbital inflammation driving melanin production, vascular dilation, and fluid retention - users should identify and address environmental allergies through appropriate medications or avoidance, manage seasonal allergies proactively before symptoms worsen, avoid rubbing eyes despite itching creating mechanical irritation and post-inflammatory hyperpigmentation, and consider antihistamine eye drops for direct ocular symptom relief

PMID: 3215057

Jaiswal et al., 2016

Some researchers start here for the first 12 weeks to assess tolerance before moving up

It can be used in concentrations of up to 10% in the EU and up to 6% in the US